The promising research showcased the results of herbicides’ uses, considering the quantitative composition of weeds with zero tillage technology of winter wheat cultivation. It revealed that when treating wheat seeds with the growth stimulator Vimpel (0.5 l/t) and micro-fertilization with Oracle (1.0 l/t) simultaneously etching with the fungicide Bunker (0.4 l/t), as well as, early spring treatment of crops in the tillering phase of winter wheat with the same stimulator (Vimpel, 0.5 l/ha) and micro-fertilization (Oracle multicomplex, 2.0 l/ha) simultaneous with the herbicide “Ballerina” (0.5 l/ha) application, the number of preserved plants before harvesting was 286.1 pcs./m², reaching a height of 88.9 cm, with a productive bushiness of 1.15 pcs., grains per spike (22.2), 1000-grain weight (34.8 g), and collected dry grains at a standard humidity (22.1 c/ha). It was also evident that the competitive productivity of winter wheat also emerged when treating wheat seeds with biological fertilizer Biobars–M (1.0 l/t), the crop at the tillering stage with Biobars–M (0.5 l/ha), and the earring phase (0.7 l/ha). Similarly, using growth stimulants Vimpel and micronutrient Oracle multicomplex enhanced the grain yield with reduced cost of production (USD 61.3–66.0/kg) compared with the control version (USD 78.6 /kg). On one hectare of winter wheat crop, the net income ranged from USD 289.55 to 443.56.

Keywords: Winter wheat (Triticum aestivum L.), zero technology, growth stimulator, biofertilizers, herbicides, productive moisture, economic efficiency, grain yield, net income

Key findings: In winter wheat, using growth regulators, micro- and biofertilizers significantly enhanced the yield variables and, eventually, the grain yield. In particular, applying growth stimulators combined with micro-fertilization increased grain yields by 2.0–2.1 times, giving winter wheat grain harvest of 1.4–2.2 t/ha, respectively.